The nearest subway station is on 42nd Street, Grand Central terminal.

149 East 39th Street, New York, NY
From LaGuardia Airport:
Take Grand Central Parkway West to Brooklyn/Queens Expressway West.
Follow Brooklyn/Queens Expressway West to the Long Island Expressway West.
Take the Long Island Expressway to Midtown Tunnel.
From Midtown Tunnel take the 34th Street exit.
Make a right onto 3rd Avenue.
Continue to 39th Street and make a left.
Murray Hill East Suites is located on the right-hand side.

From JFK International Airport:
Start out going North on 134th Street toward South Conduit Ave/NY-27 East/South Conduit Boulevard.
Turn right onto South Conduit Ave.
Continue on road and make slight turn right onto ramp.
Turn left onto 150th Street.
Turn left onto North Conduit Ave/NY-27 West.
Merge onto Van Wyck Expressway/Interstate 678 North via the ramp on the left.
Merge onto Interstate 495 West via Exit 12B (portions toll).
Keep right at the fork in the ramp.
Turn left onto East 37th Street.
Turn right onto 3rd Ave.
Turn left onto East 39th Street.